Current status and prospects for development of therapy targeting post-ischemic inflammation in ischemic stroke

Although post-ischemic stroke process is essential for the repair of infarcted area, excessive inflammation during this can induce tissue damage. Damage-associated molecular patterns (DAMPs) released from injured cells in early phase ischemic cytokine and chemokine production by activating microglia, thereby facilitating neutrophil lymphocyte infiltration. However, inhibition neutrophils, lymphocytes, their associated proinflammatory molecules has shown no apparent improvement functional outcomes prognosis stroke. Therefore, selection cell types that regulate important. Considering increase infiltration activated microglia/macrophages (M/M) major pathological change humans DAMP/toll-like receptor (TLR) signaling starting point microglial activation, regulation TLR M/M may be an important therapeutic strategy management